2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. RET
  5. RET Degrader

RET Degrader

RET Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-170852
    QZ2135
    		Degrader
    QZ2135 is a RET-targeting PROTAC degrader with in vivo antitumor properties in a Ba/F3-KIF5B-RET-G810C xenograft mouse model.
  • HY-170855A
    YW-N-7 TFA
    		Degrader
    YW-N-7 (TFA) is a PROTAC that targets both the inhibition and degradation of RET kinase, with a DC50 of 88 nM. YW-N-7 (TFA) exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse tumor model (Structure: red part represents the target protein ligand: HY-170856; blue part represents the E3 ligase ligand: HY-1708557; black part represents the linker; E3 ligase ligand + linker: HY-170858).