2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. SLC39 (Zinc Transporter)

SLC39 (Zinc Transporter)

Zinc Transporter

SLC39 is a major zinc transporter family that affects the absorption, distribution and metabolism of zinc, controls intracellular zinc homeostasis. SLC39 transporters are encoded in human by 14 genome, which are divided into four subfamilies: subfamily I includes ZIP9 that mediates the zinc transport in the Golgi apparatus; subfamily II includes ZIP1/2/3 that transports zinc from the extracellular or organelles into the cytoplasm, regulates the zinc absorption; gufA subfamily includes ZIP11 and LIV-1 subfamily includes ZIP4/5/6/7/8/10/12/13/14 that regulate zinc absorption, transport and excretion, and are related to immune system function, inflammatory response, cadmium toxicity and iron metabolism. SLC39 dysfunction causes neurodegenerative disorders, cancer, inflammation, Ehlers-Danlos syndrome and asthma[1].

SLC39 (Zinc Transporter) Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991145
    Laventatug
    		Inhibitor
    Laventatug is a humanized monoclonal antibody targeting human SLC39A6. Laventatug specifically binds to SLC39A6, interfering with the intracellular zinc ion transport process and thus exerting antitumor activity. Laventatug is promising for research of cancers.
    Laventatug