2. Signaling Pathways
  3. SWI/SNF Complex
  4. SWI/SNF Complex Degrader

SWI/SNF Complex Degrader

SWI/SNF Complex Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-170343
    PROTAC SMARCA2 degrader-32
    		Degrader
    PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for SMARCA2 with a DC50 of 1.3 nM. PROTAC SMARCA2 degrader-32 inhibits the proliferation of lung cancer cell NCI-H838 with a GI50 of 34 nM. (Pink: ligand for target protein SMARCA2 ligand-11 (HY-170349); Black: linker (HY-W895794); Blue: ligand for E3 ligase VHL (HY-170348))
  • HY-169275
    PROTAC SMARCA2 degrader-24
    		Degrader
    PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for SMARCA2 with a DC50 < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades SMARCA4 with a DC50 > 10 μM in HeLa.
  • HY-169273
    PROTAC SMARCA2 degrader-22
    		Degrader
    PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 < 250 nM.