Tyrosine Hydroxylase

TyrH, TH

Tyrosine hydroxylase (TyrH, TH) is a rate-limiting enzyme in catecholamine biosynthesis and belongs to the family of aromatic amino acid hydroxylases. Tyrosine hydroxylase uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to dopamine. The amino-terminal 150 amino acids of tyrosine hydroxylase form a domain whose structure is involved in regulating the activity of the enzyme. Regulation involves phosphorylation by multiple kinases on 4 different serine residues and dephosphorylation by 2 phosphatases. Tyrosine hydroxylase is inhibited by catecholamine neurotransmitters in a feedback manner. Dopamine competes with tetrahydrobiopterin for binding to tyrosine hydroxylase and interacts with the R domain. Tyrosine hydroxylase activity is regulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathway, structural proteins that are thought to be chaperones in mediating the oxidative state of neurons, and proteins that transfer dopamine to secretory vesicles. Tyrosine hydroxylase is modified in the presence of NO. Tyrosine hydroxylase expression maintains dopamine synthesis. Tyrosine hydroxylase is severely lost in Parkinson's disease and slightly lost in Alzheimer's disease.

References:

[1]. Daubner SC, et al. Tyrosine hydroxylase and regulation of dopamine synthesis. Arch Biochem Biophys. 2011 Apr 1;508(1):1-12. [Content Brief]

[2]. Zhu Y, et al. Overview of tyrosine hydroxylase in Parkinson's disease. CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):350-8. [Content Brief]

[3]. Torack RM, et al. Tyrosine hydroxylase-like (TH) immunoreactivity in Parkinson's disease and Alzheimer's disease. J Neural Transm Park Dis Dement Sect. 1992;4(2):165-71. [Content Brief]

Tyrosine Hydroxylase Inhibitors (2)

Tyrosine Hydroxylase Related Products (2):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-33549

α-Methyl-p-tyrosine	Inhibitor	99.41%
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases.

HY-W013407

α-Methyltyrosine methyl ester hydrochloride	Inhibitor	98.91%
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research.

Name
Email *

	Sorry, but the email address you supplied was invalid.