2. Signaling Pathways
  3. Anti-infection
  4. Urease

Urease

Urease

Urease, a nickel-containing amidohydrolase, exhibits a broad distribution across both eukaryotes and prokaryotes. It can be found in diverse organisms including invertebrates, bacteria, plants, algae, and fungi. Functionally, urease plays a crucial role in catalyzing the hydrolysis of urea, converting it into ammonia and carbon dioxide. In the context of the stomach environment, an increased ammonia content, which is a direct result of urease activity, provides favorable conditions for the survival of Helicobacter pylori. Moreover, when urease is overly active, it leads to abnormally high concentrations of ammonia. This, in turn, causes a rise in the pH of the stomach and may precipitate a series of health implications. These can range from the formation of kidney stones and the onset of pyelonephritis, to the occurrence of hepatic coma, as well as the development of peptic and gastric ulcers. Fortunately, urease inhibitors offer a potential solution as they have the capacity to mitigate the gastrointestinal problems that stem from excessive urease activity[1].

Urease Related Products (7):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147787
    Urease-IN-3
    		Inhibitor
    Urease-IN-3 (Compound L12) is a potent inhibitor of Urease with an IC50 of 1.449 μM. Urease-IN-3 is a flavonoid analogue compound.
    Urease-IN-3
  • HY-W278232
    Urease-IN-6
    		Inhibitor 98.89%
    Urease-IN-6 is a potent inhibitor of Urease with an IC50 of 14.2 μM. Urease-IN-6 can be used in study peptic and gastric ulcers .
    Urease-IN-6
  • HY-115939
    Urease-IN-2
    		Inhibitor
    Urease-IN-2 (compound 8g) is a non-competitive urease inhibitor with an IC50 of 0.94 μM and a Ki of 1.6 μM. Urease-IN-2 inhibits the Jack bean urease (JBU) in a non-competitive manner.
    Urease-IN-2
  • HY-W357738
    Urease-IN-14
    		Inhibitor
    Urease-IN-14 (compound 15) is an urease inhibitor and antioxidant. Urease-IN-14 shows DPPH radical scavenging and urease inhibitory activities with IC50 values 151.7 μM and 41.6 μM, respectively.
    Urease-IN-14
  • HY-168434
    Urease-IN-19
    		Inhibitor
    Urease-IN-19 (Compound 3c) is a potent urease inhibitor with an IC50 value of 2.7 µM. Urease-IN-19 is promising for research of kidney stones and stomach ulcers.
    Urease-IN-19
  • HY-161998
    Urease-IN-16
    		Inhibitor
    Urease-IN-16 (compound 4e) is a urease inhibitor, with an IC50 value of 132 μmol/L. Urease-IN-16 can coordinate with the nickel atom through the oxygen atoms of carbonyl or boronic acid groups. Urease-IN-16 shows great potential as an additive in the development of efficient fertilizers and medical applications.
    Urease-IN-16
  • HY-149775
    Urease-IN-10
    		Inhibitor
    Urease-IN-10 (Conjugate 4) is a competitive Urease inhibitor, with an IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. Urease-IN-10 is a conjugate consisting of Diclofenac (HY-15036) and Sulfanilamide (HY-B0242). Diclofenac-sulfanilamide inhibits the Jack bean urease(JBU) in a competitive manner.
    Urease-IN-10