2. Signaling Pathways
  3. Epigenetics
  4. WDR5
  5. WDR5 Antagonist

WDR5 Antagonist

WDR5 Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-19347
    WDR5-0103
    		Antagonist 99.93%
    WDR5-0103 (WD-Repeat Protein 5-0103) is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with a Kd of 450 nM. WDR5-0103 competitively binds to the peptide-binding pocket of WDR5, blocking the interaction between WDR5 and mixed-lineage leukemia (MLL) protein and inhibiting the methyltransferase activity of MLL. WDR5-0103 is mainly used in the research of cancer and neurodegenerative diseases.
  • HY-157659
    WDR5-MLL1 antagonist 1
    		Antagonist
    WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.