2. Metabolic Enzyme/Protease Apoptosis
  3. Dipeptidyl Peptidase Ferroptosis Apoptosis
  4. Vildagliptin dihydrate

Vildagliptin dihydrate  (Synonyms: LAF237 dihydrate; NVP-LAF 237 dihydrate)

Cat. No.: HY-14291A
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Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity.

For research use only. We do not sell to patients.

Vildagliptin dihydrate Chemical Structure

Vildagliptin dihydrate Chemical Structure

CAS No. : 2133364-01-7

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Vildagliptin dihydrate Related Antibodies

Top Publications Citing Use of Products

    Vildagliptin dihydrate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022, 23(22), 14101

    qPCR Assay. Vildagliptin (5 µM; 0, 6, 12, 24, 48, 72 h) stimulates the expression of IL-6 in HaCaT cells.

    Vildagliptin dihydrate purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 Apr 28;420:26-37.  [Abstract]

    Representative images showing visible metastatic nodules in the lungs of mice treated with Vildagliptin and fed an high-fat diet (HFD).

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    Description

    Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

    IC50 & Target

    IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]
    In Vitro

    Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Vildagliptin dihydrate Related Antibodies
    In Vivo

    Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
    Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male db/db mice (BKS) and wildtype mice[2]
    Dosage: 35 mg/kg
    Administration: Oral gavage; once daily; for 6 weeks
    Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
    Animal Model: Obese male Zucker rats[1]
    Dosage: 10 µmol/kg (Pharmacokinetic Analysis)
    Administration: Orally
    Result: Significantly decreased glucose excursions and stimulate insulin secretion.
    Clinical Trial
    Molecular Weight

    339.43

    Formula

    C17H29N3O4
    CAS No.
    SMILES

    O[C@@]1(C[C@H](C2)C3)C[C@H]3C[C@@]2(NCC(N4CCC[C@H]4C#N)=O)C1.O.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Vildagliptin dihydrate Related Classifications

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vildagliptin dihydrate2133364-01-7LAF237 dihydrateNVP-LAF 237 dihydrateDipeptidyl PeptidaseFerroptosisApoptosisDPPdipeptidylpeptidaseDPP-IVCaco-2cellsantihyperglycemicInhibitorinhibitorinhibit

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