W-2429  (Synonyms: NSC294836)

W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats^[2].

W-2429 is a non-narcotic analgesic agent. Treatment with W-2429 is well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed are decreased appetite and salivation at 100 mg/kg/day W-2429. No other significant evidence of physical, chemical, gross or histopathologic change is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

188.18

C₁₀H₈N₂O₂

37795-69-0

O=C1N(OCC2)C2=NC3=C1C=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801.  [Content Brief]

  [2]. Reisner DB, Ludwig BJ, Simon E, Dejneka T, Sofia RD. 2,3-Dihydro-9H-isoxazolo[3,2-b]quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino [3,2-b]quinazolin-10(2H)-ones. Arzneimittelforschung. 1977;27(4):766-770.  [Content Brief]