2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. β-Casomorphin, human

β-Casomorphin, human  (Synonyms: Human β-casomorphin 7)

Cat. No.: HY-P1481
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is an opioid peptide, acts as an agonist of opioid receptor.

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β-Casomorphin, human Chemical Structure

β-Casomorphin, human Chemical Structure

CAS No. : 102029-74-3

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β-Casomorphin, human Related Antibodies

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Description

is an opioid peptide, acts as an agonist of opioid receptor[1][2].

IC50 & Target

Opioid receptor[2]
In Vitro

β-Casomorphin, human TFA induces contractions of the guinea-pig ileum myenteric plexus/longitudinal muscle preparation with an IC50 of 29 μM[1].
β-Casomorphin, human TFA displaces 3H-spiperone from receptors in frontal cortex starting with 500 nM concentrations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Casomorphin, human Related Antibodies
Molecular Weight

864.00

Formula

C44H61N7O11
CAS No.
Sequence

Tyr-Pro-Phe-Val-Glu-Pro-Ile
Sequence Shortening

YPFVEPI
SMILES

CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(C([C@H](CC4=CC=C(O)C=C4)N)=O)CCC3)=O)=O)=O)=O)CCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[2]

To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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β-Casomorphin, human Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Casomorphin, human102029-74-3Human β-casomorphin 7Opioid ReceptoropioidpeptideInhibitorinhibitorinhibit

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