2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. β-Casomorphin, human TFA

β-Casomorphin, human TFA  (Synonyms: Human β-casomorphin 7 TFA)

Cat. No.: HY-P1481A Purity: 99.67%
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β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor.

For research use only. We do not sell to patients.

β-Casomorphin, human TFA Chemical Structure

β-Casomorphin, human TFA Chemical Structure

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10 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of β-Casomorphin, human TFA:

β-Casomorphin, human TFA Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor[1][2].

IC50 & Target

Opioid receptor[2]
In Vitro

β-Casomorphin, human TFA induces contractions of the guinea-pig ileum myenteric plexus/longitudinal muscle preparation with an IC50 of 29 μM[1].
β-Casomorphin, human TFA displaces 3H-spiperone from receptors in frontal cortex starting with 500 nM concentrations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Casomorphin, human TFA Related Antibodies
Molecular Weight

978.02

Formula

C46H62F3N7O13
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Pro-Phe-Val-Glu-Pro-Ile
Sequence Shortening

YPFVEPI
SMILES

OC(C(F)(F)F)=O.CC[C@@H]([C@@H](C(O)=O)NC([C@@H]1CCCN1C([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC3=CC=C(C=C3)O)N)=O)=O)CC4=CC=CC=C4)=O)=O)CCC(O)=O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (102.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0225 mL 5.1124 mL 10.2247 mL
5 mM 0.2045 mL 1.0225 mL 2.0449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (2.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0225 mL 5.1124 mL 10.2247 mL 25.5618 mL
5 mM 0.2045 mL 1.0225 mL 2.0449 mL 5.1124 mL
10 mM 0.1022 mL 0.5112 mL 1.0225 mL 2.5562 mL
15 mM 0.0682 mL 0.3408 mL 0.6816 mL 1.7041 mL
20 mM 0.0511 mL 0.2556 mL 0.5112 mL 1.2781 mL
25 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0225 mL
30 mM 0.0341 mL 0.1704 mL 0.3408 mL 0.8521 mL
40 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.6390 mL
50 mM 0.0204 mL 0.1022 mL 0.2045 mL 0.5112 mL
60 mM 0.0170 mL 0.0852 mL 0.1704 mL 0.4260 mL
80 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.3195 mL
100 mM 0.0102 mL 0.0511 mL 0.1022 mL 0.2556 mL
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β-Casomorphin, human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Casomorphin, humanHuman β-casomorphin 7Opioid ReceptoropioidpeptideInhibitorinhibitorinhibit

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