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  4. A-62198

A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses.

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A-62198 Chemical Structure

A-62198 Chemical Structure

CAS No. : 117978-26-4

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Description

A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses[1].

Molecular Weight

596.72

Formula

C30H44N8O5
CAS No.
SMILES

O[C@@H]([C@H](CN=[N+]=[N-])O)[C@@H](NC([C@H](CC1=CNC=N1)NC([C@H](CC2=CC=CC=C2)NC(C(C)C)=O)=O)=O)CC3CCCCC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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A-62198 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-62198117978-26-4A62198A 62198OthersInhibitorinhibitorinhibit

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