2. GPCR/G Protein
  3. Adenosine Receptor
  4. A2A receptor antagonist 3

A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively.

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A2A receptor antagonist 3 Chemical Structure

A2A receptor antagonist 3 Chemical Structure

CAS No. : 2738606-83-0

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A2A receptor antagonist 3 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively[1].

IC50 & Target[1]

A2AR

0.4 nM (Ki)

A2BR

37 nM (Ki)

A1R

107 nM (Ki)

A3R

1467 nM (Ki)

In Vitro

A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC50 of 0.004 μM[1].
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC50 of 0.02 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A2A receptor antagonist 3 Related Antibodies
Molecular Weight

454.52

Formula

C26H26N6O2
CAS No.
SMILES

CC(C)(O)[C@H](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A2A receptor antagonist 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A2A receptor antagonist 32738606-83-0Adenosine ReceptorP1 receptorIL-2pCREBA2aA3A2bA1Inhibitorinhibitorinhibit

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