2. Others Metabolic Enzyme/Protease
  3. Others Ser/Thr Protease
  4. AA74-1

AA74-1 is a potent and selective inhibitor of APEH. AA74-1 significantly increases T cells proliferation by blocking the APEH activity.

For research use only. We do not sell to patients.

AA74-1 Chemical Structure

AA74-1 Chemical Structure

CAS No. : 1361532-00-4

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1 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

AA74-1 Related Antibodies

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Description

AA74-1 is a potent and selective inhibitor of APEH. AA74-1 significantly increases T cells proliferation by blocking the APEH activity[1].

Molecular Weight

308.42

Formula

C16H28N4O2
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

O=C(N1N=CC(C(CC(C)C)(O)CC(C)C)=N1)N2CCCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (48.63 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2423 mL 16.2117 mL 32.4233 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2423 mL 16.2117 mL 32.4233 mL 81.0583 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL 16.2117 mL
10 mM 0.3242 mL 1.6212 mL 3.2423 mL 8.1058 mL
15 mM 0.2162 mL 1.0808 mL 2.1616 mL 5.4039 mL
20 mM 0.1621 mL 0.8106 mL 1.6212 mL 4.0529 mL
25 mM 0.1297 mL 0.6485 mL 1.2969 mL 3.2423 mL
30 mM 0.1081 mL 0.5404 mL 1.0808 mL 2.7019 mL
40 mM 0.0811 mL 0.4053 mL 0.8106 mL 2.0265 mL
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AA74-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA74-11361532-00-4OthersSer/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesAPEH InhibitorSerine hydrolaseT cellInhibitorinhibitorinhibit

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