Abd110

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Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs.

For research use only. We do not sell to patients.

Abd110 Chemical Structure

CAS No. : 3021581-79-0

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ATM ATR

Biological Activity
Purity & Documentation
References
Customer Review

Description

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs^[1].

IC₅₀ & Target^[1]

ATR

Cereblon

In Vitro

Abd110 (compound 42i; 0.5-2 μM; 24 h) selectively degrades ATR through the proteasome, dependent on the E3 ubiquitin ligase component cereblon, and without affecting the associated kinases ATM and DNA-PKcs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MIA PaCa-2 cells
Concentration:	0.5 μM, 1 μM, and 2 μM
Incubation Time:	24 h
Result:	Decreased ATR and p-ATR levels without affecting related checkpoint kinases.

Molecular Weight

790.89

Formula

C₄₁H₄₂N₈O₇S

CAS No.

3021581-79-0

SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abdallah M Alfayomy, et al. Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase. Eur J Med Chem. 2024 Mar 5:267:116167. [Content Brief]

Abd110 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abd1103021581-79-0Abd 110Abd-110PROTACsATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedPROTAC ATR kinase degraderLenalidomideCRBN,Inhibitorinhibitorinhibit

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