1. Neuronal Signaling
  2. Amyloid-β
  3. AC 253

AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.

For research use only. We do not sell to patients.

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AC 253 Chemical Structure

AC 253 Chemical Structure

CAS No. : 151804-79-4

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Description

AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM[1].

In Vitro

AC 253 (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations[1].
AC 253 (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application[2].
AC 253 (10 nM) blocks Aβ1-42-induced electrophysiological effects[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2847.11

Formula

C122H196N40O39

CAS No.
Sequence

Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Sequence Shortening

Ac-LGRLSQELHRLQTYPRTNTGSNTY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AC 253
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HY-P2285
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