AC-42

Cat. No.: HY-118806: Data Sheet Handling Instructions Technical Support

AC-42 is a poent M1 muscarinic selective allosteric agonist with EC₅₀s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells.

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AC-42 Chemical Structure

CAS No. : 244291-63-2

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Other Forms of AC-42:

AC-42 hydrochloride Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	150 nM Compound: 2, AC-42	Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	[PMID: 20684563]
CHO-K1	EC₅₀	500 nM Compound: 2, AC-42	Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	[PMID: 20684563]

Molecular Weight

301.47

Formula

C₂₀H₃₁NO

CAS No.

244291-63-2

SMILES

O=C(CCCN1CCC(CC1)CCCC)C2=CC=CC=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (269 KB) Handling Instructions (2659 KB)

References

[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. [Content Brief]

[2]. Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. [Content Brief]

AC-42 Related Classifications

Neurological Disease

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Keywords:

AC-42244291-63-2AC42AC 42mAChRMuscarinic acetylcholine receptorM1 muscarinicallostericwild-typeY381AInhibitorinhibitorinhibit

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AC-42

Other Forms of AC-42:

View All mAChR Isoform Specific Products:

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