2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2

Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure.

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Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 Chemical Structure

Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 Chemical Structure

CAS No. : 819048-44-7

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Based on 1 publication(s) in Google Scholar

Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 Related Antibodies

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MC1R MC3R MC2R MC4R MC5R

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Description

Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1].

Molecular Weight

1175.35

Formula

C51H70N18O11S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-{d-Arg}-Cys-Glu-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge: Cys2-Cys8)
Sequence Shortening

Ac-{d-Arg}-CEH-{d-Phe}-RWC-NH2 (Disulfide bridge: Cys2-Cys8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 43.4 mg/mL (36.93 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8508 mL 4.2541 mL 8.5081 mL
5 mM 0.1702 mL 0.8508 mL 1.7016 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8508 mL 4.2541 mL 8.5081 mL 21.2703 mL
5 mM 0.1702 mL 0.8508 mL 1.7016 mL 4.2541 mL
10 mM 0.0851 mL 0.4254 mL 0.8508 mL 2.1270 mL
15 mM 0.0567 mL 0.2836 mL 0.5672 mL 1.4180 mL
20 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0635 mL
25 mM 0.0340 mL 0.1702 mL 0.3403 mL 0.8508 mL
30 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7090 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2819048-44-7Melanocortin ReceptorMC ReceptorMC4R agonistInhibitorinhibitorinhibit

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