2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Ac-Lys-Val-Cit-PABC-MMAE

Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162).

For research use only. We do not sell to patients.

Ac-Lys-Val-Cit-PABC-MMAE Chemical Structure

Ac-Lys-Val-Cit-PABC-MMAE Chemical Structure

CAS No. : 1650569-89-3

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5 mg USD 240 In-stock
10 mg USD 390 In-stock
25 mg USD 780 In-stock
50 mg USD 1240 In-stock
100 mg USD 1980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ac-Lys-Val-Cit-PABC-MMAE:

Ac-Lys-Val-Cit-PABC-MMAE Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1].

IC50 & Target

Auristatin

 

Molecular Weight

1293.64

Formula

C66H108N12O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (154.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7730 mL 3.8651 mL 7.7301 mL
5 mM 0.1546 mL 0.7730 mL 1.5460 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7730 mL 3.8651 mL 7.7301 mL 19.3253 mL
5 mM 0.1546 mL 0.7730 mL 1.5460 mL 3.8651 mL
10 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9325 mL
15 mM 0.0515 mL 0.2577 mL 0.5153 mL 1.2884 mL
20 mM 0.0387 mL 0.1933 mL 0.3865 mL 0.9663 mL
25 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7730 mL
30 mM 0.0258 mL 0.1288 mL 0.2577 mL 0.6442 mL
40 mM 0.0193 mL 0.0966 mL 0.1933 mL 0.4831 mL
50 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3865 mL
60 mM 0.0129 mL 0.0644 mL 0.1288 mL 0.3221 mL
80 mM 0.0097 mL 0.0483 mL 0.0966 mL 0.2416 mL
100 mM 0.0077 mL 0.0387 mL 0.0773 mL 0.1933 mL
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Ac-Lys-Val-Cit-PABC-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Lys-Val-Cit-PABC-MMAE1650569-89-3Drug-Linker Conjugates for ADCcancerInhibitorinhibitorinhibit

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