Ac2-12

Cat. No.: HY-P1099 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

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Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models.

For research use only. We do not sell to patients.

Ac2-12 Chemical Structure

CAS No. : 256447-08-2

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Other Forms of Ac2-12:

Ac2-12 TFA Get quote

1 Publications Citing Use of MCE Ac2-12

•Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]

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Purity & Documentation
References
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Description

Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models^[1]^[2].

In Vivo

Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)^[1].
Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1351.57

Formula

C₆₃H₉₄N₁₄O₁₇S

CAS No.

256447-08-2

Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-AMVSEFLKQAW

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (36.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7399 mL	3.6994 mL	7.3988 mL
5 mM	0.1480 mL	0.7399 mL	1.4798 mL
10 mM	0.0740 mL	0.3699 mL	0.7399 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (244 KB) RP-HPLC (110 KB) MS (217 KB)

Handling Instructions (2659 KB)

References

[1]. L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9. [Content Brief]

[2]. M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.7399 mL	3.6994 mL	7.3988 mL	18.4970 mL
	5 mM	0.1480 mL	0.7399 mL	1.4798 mL	3.6994 mL
	10 mM	0.0740 mL	0.3699 mL	0.7399 mL	1.8497 mL
	15 mM	0.0493 mL	0.2466 mL	0.4933 mL	1.2331 mL
	20 mM	0.0370 mL	0.1850 mL	0.3699 mL	0.9249 mL
	25 mM	0.0296 mL	0.1480 mL	0.2960 mL	0.7399 mL
	30 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.6166 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Ac2-12 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac2-12256447-08-2OthersInhibitorinhibitorinhibit

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