Acetyl-Calpastatin(184-210)(human)

Name: Acetyl-Calpastatin(184-210)(human)
Brand: MedChemExpress
SKU: HY-P1081
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1081 Purity: 98.20%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Acetyl-Calpastatin(184-210)(human) Chemical Structure

CAS No. : 123714-50-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acetyl-Calpastatin(184-210)(human):

Acetyl-Calpastatin(184-210)(human) TFA Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively^[1]^[2].

In Vitro

Acetyl-Calpastatin(184-210)(human) (peptide 1; 12.5-100 μM) inhibits calpains in LCLC 103H cells with an IC₅₀ of 27 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3177.63

Formula

C₁₄₂H₂₃₀N₃₆O₄₄S

CAS No.

123714-50-1

Appearance

Solid

Color

White to off-white

Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Sequence Shortening

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (31.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3147 mL	1.5735 mL	3.1470 mL
5 mM	0.0629 mL	0.3147 mL	0.6294 mL
10 mM	0.0315 mL	0.1573 mL	0.3147 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.20%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (242 KB) RP-HPLC (268 KB) Elemental Analysis Report (100 KB)

Handling Instructions (2659 KB)

References

[1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3. [Content Brief]

[2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3147 mL	1.5735 mL	3.1470 mL	7.8675 mL
	5 mM	0.0629 mL	0.3147 mL	0.6294 mL	1.5735 mL
	10 mM	0.0315 mL	0.1573 mL	0.3147 mL	0.7867 mL
	15 mM	0.0210 mL	0.1049 mL	0.2098 mL	0.5245 mL
	20 mM	0.0157 mL	0.0787 mL	0.1573 mL	0.3934 mL
	25 mM	0.0126 mL	0.0629 mL	0.1259 mL	0.3147 mL
	30 mM	0.0105 mL	0.0524 mL	0.1049 mL	0.2622 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.