Acetyl-L-carnitine-d₃-1 hydrochloride (Synonyms: O-Acetyl-L-carnitine-d₃-1 (hydrochloride))

Name: Acetyl-L-carnitine-d 3 -1 hydrochloride
Brand: MedChemExpress
SKU: HY-B0762S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0762S1 Purity: 98.5%: FAQs
Data Sheet SDS COA Handling Instructions

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Acetyl-L-carnitine-d₃-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].

For research use only. We do not sell to patients.

Acetyl-L-carnitine-d<sub>3</sub>-1 hydrochloride Chemical Structure

Acetyl-L-carnitine-d₃-1 hydrochloride Chemical Structure

CAS No. : 362049-62-5

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
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100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Acetyl-L-carnitine-d₃-1 hydrochloride:

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

242.72

Formula

C₉H₁₅D₃ClNO₄

CAS No.

362049-62-5

Unlabeled CAS

5080-50-2

Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(C)C[C@H](OC(C([2H])([2H])[2H])=O)CC(O)=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1029.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1200 mL	20.5999 mL	41.1997 mL
5 mM	0.8240 mL	4.1200 mL	8.2399 mL
10 mM	0.4120 mL	2.0600 mL	4.1200 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (412.00 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.5%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Marcon M, et al. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model. Neuropharmacology. 2019 May 15;150:145-152. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.1200 mL	20.5999 mL	41.1997 mL	102.9993 mL
	5 mM	0.8240 mL	4.1200 mL	8.2399 mL	20.5999 mL
	10 mM	0.4120 mL	2.0600 mL	4.1200 mL	10.2999 mL
	15 mM	0.2747 mL	1.3733 mL	2.7466 mL	6.8666 mL
	20 mM	0.2060 mL	1.0300 mL	2.0600 mL	5.1500 mL
	25 mM	0.1648 mL	0.8240 mL	1.6480 mL	4.1200 mL
	30 mM	0.1373 mL	0.6867 mL	1.3733 mL	3.4333 mL
	40 mM	0.1030 mL	0.5150 mL	1.0300 mL	2.5750 mL
	50 mM	0.0824 mL	0.4120 mL	0.8240 mL	2.0600 mL
	60 mM	0.0687 mL	0.3433 mL	0.6867 mL	1.7167 mL
	80 mM	0.0515 mL	0.2575 mL	0.5150 mL	1.2875 mL
	100 mM	0.0412 mL	0.2060 mL	0.4120 mL	1.0300 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Acetyl-L-carnitine-d₃-1 hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetyl-L-carnitine-d₃-1362049-62-5O-Acetyl-L-carnitine-d₃-1Endogenous MetaboliteInhibitorinhibitorinhibit

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Acetyl-L-carnitine-d3-1 hydrochloride (Synonyms: O-Acetyl-L-carnitine-d3-1 (hydrochloride))

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Other Forms of Acetyl-L-carnitine-d3-1 hydrochloride:

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Complete Stock Solution Preparation Table

Acetyl-L-carnitine-d3-1 hydrochloride Related Classifications

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Acetyl-L-carnitine-d₃-1 hydrochloride (Synonyms: O-Acetyl-L-carnitine-d₃-1 (hydrochloride))

Other Forms of Acetyl-L-carnitine-d₃-1 hydrochloride:

Acetyl-L-carnitine-d₃-1 hydrochloride Related Antibodies

Acetyl-L-carnitine-d₃-1 hydrochloride Related Antibodies

Acetyl-L-carnitine-d₃-1 hydrochloride Related Classifications