2. GPCR/G Protein
  3. Endothelin Receptor
  4. ACT-373898

ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.

For research use only. We do not sell to patients.

ACT-373898 Chemical Structure

ACT-373898 Chemical Structure

CAS No. : 1433875-14-9

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ACT-373898 Related Antibodies

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Description

ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

In Vitro

The elimination half-life (t1/2) is approximately 16 h for Macitentan, and ACT-373898 has a similar pharmacokinetic (PK) profile to Macitentan[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACT-373898 Related Antibodies
Molecular Weight

445.29

Formula

C15H17BrN4O5S
CAS No.
SMILES

O=C(O)COC1=NC=NC(NS(=O)(NCCC)=O)=C1C2=CC=C(Br)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ACT-373898 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACT-3738981433875-14-9ACT373898ACT 373898Endothelin ReceptorMacitentancarboxylicacidmetaboliteendothelinInhibitorinhibitorinhibit

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HY-135500
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