2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine receptor inhibitor 2

Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR.

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Adenosine receptor inhibitor 2 Chemical Structure

Adenosine receptor inhibitor 2 Chemical Structure

CAS No. : 2550401-76-6

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Adenosine receptor inhibitor 2 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR[1].

IC50 & Target

A1AR

52.2 ± 8.5 nM (Ki)

A2AR

167 ± 22 nM (Ki)

hA2B

>1000 nM (Ki)

Adenosine A3 receptor

>1000 nM (Ki)

Molecular Weight

406.28

Formula

C17H20BrN5O2
CAS No.
SMILES

O=C(N1CC)N(CC)C2=C(N(C)C(NCC3=CC=CC(Br)=C3)=N2)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Adenosine receptor inhibitor 2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine receptor inhibitor 22550401-76-6Adenosine receptor inhibitor2Adenosine receptor inhibitor-2Adenosine ReceptorP1 receptorAdenosine A2A receptorsAnti-inflammatory activityMetabolic stabilityMonoamine oxidasePhosphodiesteraseXanthine derivativesGPCRInhibitorinhibitorinhibit

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