2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK-IN-38

JAK-IN-38 (Compound 1) is a JAK inhibitor, with IC50s of 0.03, 0.06, 0.12, 0.44 μM for Tyk2, JAK3, JAK2, JAK1 respectively. JAK-IN-38 is a collagen VII (C7) inducer and has anti-inflammatory activity. JAK-IN-38 can upregulate the expression of COL7A1 mRNA in donor-derived keratinocytes and works together with Gentamicin (HY-A0276A) to boost overall C7 levels.

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JAK-IN-38 Chemical Structure

JAK-IN-38 Chemical Structure

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JAK-IN-38 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

JAK-IN-38 (Compound 1) is a JAK inhibitor, with IC50s of 0.03, 0.06, 0.12, 0.44 μM for Tyk2, JAK3, JAK2, JAK1 respectively. JAK-IN-38 is a collagen VII (C7) inducer and has anti-inflammatory activity. JAK-IN-38 can upregulate the expression of COL7A1 mRNA in donor-derived keratinocytes and works together with Gentamicin (HY-A0276A) to boost overall C7 levels[1].
IC50 & Target[1]

Tyk2

0.03 μM (IC50)

JAK3

0.06 μM (IC50)

JAK2

0.12 μM (IC50)

JAK1

0.44 μM (IC50)

Molecular Weight

460.53

Formula

C25H28N6O3
SMILES

[H][C@@]1(C2CC3CC1C[C@@](C3)(C2)O)NC(C4=C(N=CC(C5=CC=C6C=CN(C6=C5)CC(N)=O)=N4)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK-IN-38 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK-IN-38JAKJanus kinasecollagen VIICOL7A1 mRNAkeratinocytesInhibitorinhibitorinhibit

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HY-162862
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