2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ADTL-EI1712

ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo.

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ADTL-EI1712 Chemical Structure

ADTL-EI1712 Chemical Structure

CAS No. : 2414916-45-1

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ADTL-EI1712 Related Antibodies

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Description

ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 50 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
HL-60 IC50
1.26 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
MKN-74 IC50
2.55 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
In Vitro

ADTL-EI1712 shows antiproliferative activity against HL-60, MKN-74 and HeLa cells, with IC50 values of 1.26+0.57, 2.55+0.66, >50 μM, respectively[1].
ADTL-EI1712 (0.5 μM, 24 h) induces regulated cell death accompanied by autophagy in MKN-74 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADTL-EI1712 Related Antibodies
In Vivo

ADTL-EI1712 (50 mg/kg, PO, once a day for 16 days) significantly inhibits the tumor volume in the xenograft mouse model of HL-60 and MKN-74 cells, while the antitumor effect of HeLa cells group was much weaker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

505.44

Formula

C22H18Cl2N4O2S2
CAS No.
SMILES

O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADTL-EI1712 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADTL-EI17122414916-45-1ERKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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