2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy Apoptosis PI3K/Akt/mTOR MAPK/ERK Pathway
  3. EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK
  4. Afatinib (Standard)

Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

For research use only. We do not sell to patients.

Afatinib (Standard) Chemical Structure

Afatinib (Standard) Chemical Structure

CAS No. : 850140-72-6

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  • Do most proteins show cross-species activity?

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Keywords:

Afatinib (Standard)850140-72-6EGFRAutophagyApoptosisc-Met/HGFRAktp38 MAPKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BNSCLCH1666H3255NCI-H1975NIH-3T3 cellsA431ESCCHER2AKTHKESC-1HKESC-2SLMT-1EC-1anticancerorally activelung cancerInhibitorinhibitorinhibit

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