2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. Bcr-Abl FGFR Raf RET VEGFR
  4. AFG210

AFG210 is a potent multi-target kinase inhibitor that primarily inhibits Abl kinase (IC50=330 nM), and also has inhibitory effects on other kinases such as B-Raf, C-Raf, FGFR-1, RET and VEGF receptors. AFG210 can be used to study chronic myeloid leukemia and other diseases with abnormal activation of Abl kinase.

For research use only. We do not sell to patients.

AFG210 Chemical Structure

AFG210 Chemical Structure

CAS No. : 228400-22-4

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AFG210 Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

AFG210 is a potent multi-target kinase inhibitor that primarily inhibits Abl kinase (IC50=330 nM), and also has inhibitory effects on other kinases such as B-Raf, C-Raf, FGFR-1, RET and VEGF receptors. AFG210 can be used to study chronic myeloid leukemia and other diseases with abnormal activation of Abl kinase[1].

Molecular Weight

373.33

Formula

C19H14F3N3O2
CAS No.
SMILES

O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=CC(C(F)(F)F)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AFG210 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFG210228400-22-4AFG 210AFG-210Bcr-AblFGFRRafRETVEGFRFibroblast growth factor receptorRaf kinasesVascular endothelial growth factor receptorMulti-target inhibitorMyeloid leukemiaAbl kinaseInhibitorinhibitorinhibit

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