2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. AG-012986

AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis.

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AG-012986 Chemical Structure

AG-012986 Chemical Structure

CAS No. : 486414-35-1

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AG-012986 Related Antibodies

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Description

AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis[1].

IC50 & Target[1]

Cdk1/cyclin B

44 nM (Ki)

cdk2/cyclin A

94 nM (Ki)

CDK4

9.2 nM (Ki)

CDK5/p35

22 nM (IC50)

CDK9/Cyclin T

4 nM (IC50)

Molecular Weight

459.51

Formula

C22H23F2N5O2S
CAS No.
SMILES

O=C(C1=CC=C(C=C1)NC2=NC(N)=C(S2)C(C3=C(C=CC=C3F)F)=O)N[C@@H](CN(C)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AG-012986 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG-012986486414-35-1AG012986AG 012986CDKApoptosisCyclin dependent kinaseantitumorCDK inhibitionInhibitorinhibitorinhibit

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