Aglepristone

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Aglepristone is a synthetic steroidal antiprogestin with abortifacient activity. Aglepristone is used exclusively as an abortifacient in pregnant animals. Aglepristone has been shown to be a safe and effective abortifacient in the second trimester of pregnancy. Aglepristone causes termination of pregnancy and does not cause fetal resorption. During aglepristone treatment, an increase in plasma concentrations of prolactin was observed, while progesterone levels remained unchanged. The use of aglepristone also resulted in early arrest of corpus luteum function and a shortening of the estrus interval.

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Aglepristone Chemical Structure

CAS No. : 124478-60-0

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Description	Aglepristone is a synthetic steroidal antiprogestin with abortifacient activity. Aglepristone is used exclusively as an abortifacient in pregnant animals. Aglepristone has been shown to be a safe and effective abortifacient in the second trimester of pregnancy. Aglepristone causes termination of pregnancy and does not cause fetal resorption. During aglepristone treatment, an increase in plasma concentrations of prolactin was observed, while progesterone levels remained unchanged. The use of aglepristone also resulted in early arrest of corpus luteum function and a shortening of the estrus interval^[1].
Molecular Weight	431.61
Formula	C₂₉H₃₇NO₂
CAS No.	124478-60-0
SMILES	C[C@@]12[C@](CC[C@@]2(O)/C=C\C)([H])[C@@]3([H])C([C@@H](C4=CC=C(C=C4)N(C)C)C1)=C5C(CC3)=CC(CC5)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist

Aglepristone Related Classifications

Endocrinology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aglepristone124478-60-0Endogenous MetaboliteInhibitorinhibitorinhibit

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Aglepristone

Aglepristone Related Antibodies

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