2. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. Antibody-Drug Conjugates (ADCs) Phosphodiesterase (PDE)
  4. AGS-16C3F

AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a MMAF.html" target="_blank" style="color: #6a4b92; font-weight:bold;">McMMAF (MMAF.html" target="_blank" style="color: #6a4b92; font-weight:bold;">HY-15578) linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC).

For research use only. We do not sell to patients.

AGS-16C3F Chemical Structure

AGS-16C3F Chemical Structure

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AGS-16C3F Related Antibodies

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Description

AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a MMAF.html" target="_blank" style="color: #6a4b92; font-weight:bold;">McMMAF (MMAF.html" target="_blank" style="color: #6a4b92; font-weight:bold;">HY-15578) linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC)[1][2].

IC50 & Target

PDE3

 

In Vitro

AGS-16C3F (0.001-1350 nM, 96 h) has IC50 of 1.1 nM, 2.73 nM, 109.9 nM and 146.5 nM in ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells, respectively, shows potent inhibitory activity against the proliferation of ROSA cells with high expression of CD203c[2].
AGS-16C3F (0.5-100 nM, 96-120 h) induces apoptosis and kills tumor cells with high expression of CD203c in ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGS-16C3F Related Antibodies

Apoptosis Analysis[2]

Cell Line: ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells
Concentration: 0.5-100 nM
Incubation Time: 96-120 h
Result: Significantly increased the proportion of apoptotic cells in ROSA cells (dose-dependent).
Had a low apoptosis rate in HMC-1 cells.
In Vivo

AGS-16C3F (1,4 mg/kg, i.v. once every 4 days, 4 times in total) significantly reduces tumor burden and prolongs survival in the NOD-SCID γ mice model transplants with ROSA KIT D816V-Gluc cells without significant toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-SCID γ mice injected with ROSA KIT D816V-Gluc (5 million cells)[2]
Dosage: 1,4 mg/kg
Administration: i.v. once every 4 days, 4 times in total
Result: Significantly reduced the number of tumor cells in peripheral blood, bone marrow, and spleen, and decreased serum tryptase levels.
During treatment and after drug withdrawal, the luciferase activity (marker of tumor burden) of mice in the high-dose group continued to be lower than that in the control group, and disease recurrence was delayed.
Significantly prolonged the survival of mice.
Showed a significant increase in apoptotic cells in the mouse bone marrow, indicating that the anti-tumor effect was mainly achieved by inducing apoptosis.
SMILES

[AGS-16C3F]
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AGS-16C3F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGS-16C3FAGS-16M8FAntibody-Drug Conjugates (ADCs)Phosphodiesterase (PDE)Antibody-Drug ConjugatesMrccADCsROSA KIT D816V cellsHMC cellsInhibitorinhibitorinhibit

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