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AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells.

For research use only. We do not sell to patients.

AI-10-104 Chemical Structure

AI-10-104 Chemical Structure

CAS No. : 1881276-00-1

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Description

AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells[1].

In Vitro

AI-10-104 (0-10 μM) inhibits the RUNX through dissociation of RUNXs-IKZFs complex, enhances the anti-proliferative effect of lenalidomide and its cytotoxicity in myeloma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293T
Concentration: 0-10 μM
Incubation Time:
Result: Decreased levels of IKZF3 and CBFβ.

Cell Proliferation Assay[1]

Cell Line: OPM-1 cells, KMS-11 and U266 cells
Concentration: 1 μM
Incubation Time:
Result: Maintained the cell viability, inhibited proliferation of OPM-1 cells in a moderate effect.
Molecular Weight

309.24

Formula

C14H10F3N3O2

CAS No.
SMILES

FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3OC)NC2=C1

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
AI-10-104
Cat. No.:
HY-122657
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