AIE-Cbz-LD-C7

Cat. No.: HY-151468: FAQs
Data Sheet Handling Instructions

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AIECbz-LD-C7 is an aggregation-induced emission (AIE) probe based on the conjugation of quinoline-malononitrile (QM) and carbazole. AIECbz-LD-C7 has excellent LD-specificity. AIECbz-LD-C7 can be used for tracking the dynamic changes of LDs and studying the association between LDs and lysosome/endoplasmic reticulum (ER).

For research use only. We do not sell to patients.

AIE-Cbz-LD-C7 Chemical Structure

CAS No. : 2810130-33-5

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Description

In Vitro

AIE-Cbz-LD-C (0, 2, 5, 10, 20, and 30 μM; 24 h) have excellent biocompatibility^[1].
AIECbz-LD-C7 (0.5 μM, 15 min) could aggregate in LDs accurately and light up the LDs with good photostability^[1].
AIE-Cbz-LD-C7 (0.5 μM) can be used to visualize the interplay between LDs and lysosomes during lipophag due to the excellent LD-specificity^[1].
AIE-Cbz-LD-C7 (0.5 μM, 15 min) increases the number of ferroptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HepG2 cells
Concentration:	0, 2, 5, 10, 20, and 30 μM
Incubation Time:	24 h
Result:	Displayed favorable viability with a value above 90%.

Molecular Weight

510.67

Formula

C₃₅H₃₄N₄

CAS No.

2810130-33-5

SMILES

CCCCCCCN1C2=C(C3=C1C=CC(/C=C/C4=C/C(C5=CC=CC=C5N4CC)=C(C#N)/C#N)=C3)C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rui Chen, et al. Rational Design of Novel Lipophilic Aggregation-Induced Emission Probes for Revealing the Dynamics of Lipid Droplets during Lipophagy and Ferroptosis. Anal Chem. 2022 Sep 19. [Content Brief]

AIE-Cbz-LD-C7 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AIE-Cbz-LD-C72810130-33-5OthersLipid droplets (LDs)quinoline-malononitrile (QM)aggregation-induced emission (AIE)lysosome/endoplasmic reticulum (ER)bioimagingInhibitorinhibitorinhibit

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