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  4. AKR1C3-IN-6

AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity.

For research use only. We do not sell to patients.

AKR1C3-IN-6 Chemical Structure

AKR1C3-IN-6 Chemical Structure

CAS No. : 2137881-54-8

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AKR1C3-IN-6 Related Antibodies

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Description

AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1].

IC50 & Target

IC50: 0.31 μM (AKR1C3), 73.23 μM (AKR1C2)[1]
Cellular Effect
Cell Line Type Value Description References
CWR22R IC50
81.4 μM
Compound: 1
Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 35447434]
CWR22R IC50
81.4 μM
Compound: 1
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric assay
[PMID: 29602039]
CWR22R IC50
81.4 μM
Compound: 8
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay
Antiproliferative activity against human 22Rv1 cells after 72 hrs by sulforhodamine B colorimetric proliferation assay
[PMID: 28881288]
In Vitro

AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC50 of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AKR1C3-IN-6 Related Antibodies
Molecular Weight

392.33

Formula

C18H15F3N4O3
CAS No.
SMILES

COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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AKR1C3-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKR1C3-IN-62137881-54-8Others22rv1prostate cancerantitumorInhibitorinhibitorinhibit

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