AKT-IN-18

Cat. No.: HY-149842: FAQs
Data Sheet Handling Instructions

Molarity Calculator

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC₅₀ of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study.

For research use only. We do not sell to patients.

AKT-IN-18 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Akt Isoform Specific Products:

View All Isoforms

Akt Akt1 Akt2 Akt3

Biological Activity
Purity & Documentation
References
Customer Review

Description

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC₅₀ of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study^[1].

IC₅₀ & Target^[1]

Akt

69.45 μM (IC₅₀)

In Vitro

AKT-IN-18 (Compound 3i) (0-500 μM; 24 hours) exerts cytotoxic activity against A549 cells, and induces apoptosis ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	A549, L929 cells
Concentration:	0-500 μM
Incubation Time:	24 hours
Result:	Exerted cytotoxic activity against A549 cells with IC₅₀ of 83.59 μΜ without influencing normal (L929) cells at effective doses. Induced early apoptosis caused at 2.7% and late apoptotic cells at 6.04%.

Molecular Weight

411.86

Formula

C₁₉H₁₄ClN₅O₂S

SMILES

O=C(N/N=C/C1=CC=C(N2C=CN=C2)C=C1)CSC3=NC4=CC(Cl)=CC=C4O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Erdönmez B,et.al. Design, Synthesis, and Evaluation of a New Series of Hydrazones as Small-Molecule Akt Inhibitors for NSCLC Therapy. ACS Omega. 2023 May 24;8(22):20056-20065. [Content Brief]

AKT-IN-18 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-18AktApoptosisPKBProtein kinase BAkt InhibitorA549L929Non-Small-Cell Lung CarcinomaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks