2. PI3K/Akt/mTOR Apoptosis
  3. Akt Apoptosis
  4. AKT-IN-18

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC50 of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study.

For research use only. We do not sell to patients.

AKT-IN-18 Chemical Structure

AKT-IN-18 Chemical Structure

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AKT-IN-18 Related Antibodies

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Description

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC50 of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study[1].

IC50 & Target[1]

Akt

69.45 μM (IC50)

In Vitro

AKT-IN-18 (Compound 3i) (0-500 μM; 24 hours) exerts cytotoxic activity against A549 cells, and induces apoptosis [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-18 Related Antibodies

Apoptosis Analysis[1]

Cell Line: A549, L929 cells
Concentration: 0-500 μM
Incubation Time: 24 hours
Result: Exerted cytotoxic activity against A549 cells with IC50 of 83.59 μΜ without influencing normal (L929) cells at effective doses.
Induced early apoptosis caused at 2.7% and late apoptotic cells at 6.04%.
Molecular Weight

411.86

Formula

C19H14ClN5O2S
SMILES

O=C(N/N=C/C1=CC=C(N2C=CN=C2)C=C1)CSC3=NC4=CC(Cl)=CC=C4O3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AKT-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-18AktApoptosisPKBProtein kinase BAkt InhibitorA549L929Non-Small-Cell Lung CarcinomaInhibitorinhibitorinhibit

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HY-149842
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