Akt/NF-κB/JNK-IN-1 

Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC₅₀ of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities^[1].

Akt/NF-κB/JNK-IN-1 (Compound 2i) (0-50 μM) significantly reduces the levels of TNF-α, IL-1β, IL-6 and PGE2 and markedly downregulates the expression levels of iNOS and COX-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

410.42

C₂₂H₂₂N₂O₆

CN1CCN(CC1)CC(OCC2=CC3=C(C(O)=C2)C(C4=C(C=CC=C4C3=O)O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shang H, et al. Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways. Eur J Med Chem. 2022 Aug 5;238:114511.  [Content Brief]