2. PI3K/Akt/mTOR
  3. Akt
  4. AKT1-IN-9

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively.

For research use only. We do not sell to patients.

AKT1-IN-9 Chemical Structure

AKT1-IN-9 Chemical Structure

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AKT1-IN-9 Related Antibodies

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Description

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively[1].

IC50 & Target[1]

AKT1(E17K)

 

In Vivo

AKT1-IN-9 (4) (40 mg/kg, i.p. injection, single dose) reduces phospho-AKT1 and phospho-PRAS40 levels in tumours collected at 2 h and 7 h postdose (80-90% inhibition)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

572.59

Formula

C33H25FN6O3
SMILES

O=C(CC1=CC=C(C([H])=O)C(O)=C1F)NCC(C=C2)=CC=C2N3C(C4=C(N)N=CC=C4)=NC5=C3N=C(C=C5)C6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AKT1-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT1-IN-9AktPKBProtein kinase BAKT1E17KLAPC4-CRSkBr3Inhibitorinhibitorinhibit

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