1. PI3K/Akt/mTOR
  2. Akt
  3. AKT1-IN-9

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively.

For research use only. We do not sell to patients.

AKT1-IN-9 Chemical Structure

AKT1-IN-9 Chemical Structure

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Description

AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively[1].

IC50 & Target[1]

AKT1(E17K)

 

In Vivo

AKT1-IN-9 (4) (40 mg/kg, i.p. injection, single dose) reduces phospho-AKT1 and phospho-PRAS40 levels in tumours collected at 2 h and 7 h postdose (80-90% inhibition)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

572.59

Formula

C33H25FN6O3

SMILES

O=C(CC1=CC=C(C([H])=O)C(O)=C1F)NCC(C=C2)=CC=C2N3C(C4=C(N)N=CC=C4)=NC5=C3N=C(C=C5)C6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
AKT1-IN-9
Cat. No.:
HY-173155
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