AL-GDa62

Cat. No.: HY-145269: FAQs
Data Sheet Handling Instructions

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AL-GDa62 acts as a potential synthetic lethal lead for the research of gastric cancer. AL-GDa62 shows EC₅₀ of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild-type) and MCF10A-CDH1^-/-.

For research use only. We do not sell to patients.

AL-GDa62 Chemical Structure

CAS No. : 2761538-66-1

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	EC₅₀	2 μM Compound: 3;AL-GDa62	Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
MCF-10A	EC₅₀	3.2 μM Compound: 3;AL-GDa62	Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
NCI-N87	EC₅₀	16.35 μM Compound: 3;AL-GDa62	Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]
NCI-N87	EC₅₀	8.5 μM Compound: 3;AL-GDa62	Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs	[PMID: 34878770]

Molecular Weight

393.50

Formula

C₂₄H₂₈FN₃O

CAS No.

2761538-66-1

SMILES

FC(C=C1)=CC=C1CNC2=CC(C)=NC3=C2C=C(OCCCN4CCCC4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64(24):18114-18142. [Content Brief]

AL-GDa62 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-GDa622761538-66-1Otherssynthetic lethal leadgastric cancerisogenic mammary epithelial cellsMCF10A-WTInhibitorinhibitorinhibit

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