Alcaftadine carboxylic acid-d₃ sodium

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Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01%.

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Alcaftadine carboxylic acid-d<sub>3</sub> sodium Chemical Structure

Alcaftadine carboxylic acid-d₃ sodium Chemical Structure

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Other Forms of Alcaftadine carboxylic acid-d₃ sodium:

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Description	Alcaftadine carboxylic acid-d₃ (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01%^[1]^[2].
Molecular Weight	348.39
Formula	C₁₉H₁₇D₃N₃NaO₂
SMILES	O=C(C1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C([2H])([2H])[2H])CC\4)O[Na]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Alcaftadine: a topical antihistamine for use in allergic conjunctivitis [Content Brief]