Alclometasone  (Synonyms: 7a-​Chloro-​16a-​methyl prednisolone)

Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic?dermatitis, eczema, psoriasis and allergic dermatitis^[1].

IC50: glucocorticoid receptor^[1]

The prodrug of alclometasone is alclometasone dipropionate^[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

408.92

C₂₂H₂₉ClO₅

67452-97-5

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• [1]. Alclometasone

  [2]. Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50(4):435-43.  [Content Brief]