2. TGF-beta/Smad Stem Cell/Wnt
  3. TGF-β Receptor TGF-beta/Smad
  4. ALK5-IN-32

ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nM<IC50<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis.

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ALK5-IN-32 Chemical Structure

ALK5-IN-32 Chemical Structure

CAS No. : 2785430-88-6

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ALK5-IN-32 Related Antibodies

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Description

ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nM<IC50<100 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].

IC50 & Target

ALK-5[1].
Molecular Weight

430.48

Formula

C23H23FN8
CAS No.
SMILES

CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3F)C=NN=C12
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALK5-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-322785430-88-6TGF-β ReceptorTGF-beta/SmadTransforming growth factor beta receptorsTransforming growth factor betatumourcancerTGFβR1proliferative diseasesfibrotic diseasessystemic sclerosisInhibitorinhibitorinhibit

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