ALK5-IN-33

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ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC₅₀ ≤10 nM.

For research use only. We do not sell to patients.

ALK5-IN-33 Chemical Structure

CAS No. : 2785430-89-7

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

Biological Activity
Purity & Documentation
References
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Description

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC₅₀ ≤10 nM^[1].

IC₅₀ & Target

ALK5

≤10 nM (IC₅₀)

ALK2

In Vitro

ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice, A549 xenograft model^[1]
Dosage:	10, 50, 75 and 100 mg/kg
Administration:	Oral gavage, once
Result:	Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.

Molecular Weight

413.48

Formula

C₂₃H₂₃N₇O

CAS No.

2785430-89-7

SMILES

CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=NN=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

ALK5-IN-33 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-332785430-89-7TGF-β ReceptorTransforming growth factor beta receptorsALK-5ALK-2antitumorInhibitorinhibitorinhibit

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