2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ALK5-IN-33

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM.

For research use only. We do not sell to patients.

ALK5-IN-33 Chemical Structure

ALK5-IN-33 Chemical Structure

CAS No. : 2785430-89-7

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ALK5-IN-33 Related Antibodies

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Description

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].

IC50 & Target

ALK5

≤10 nM (IC50)

ALK2

 

In Vitro

ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALK5-IN-33 Related Antibodies
In Vivo

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice, A549 xenograft model[1]
Dosage: 10, 50, 75 and 100 mg/kg
Administration: Oral gavage, once
Result: Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
Molecular Weight

413.48

Formula

C23H23N7O
CAS No.
SMILES

CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=NN=C12
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALK5-IN-33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-332785430-89-7TGF-β ReceptorTransforming growth factor beta receptorsALK-5ALK-2antitumorInhibitorinhibitorinhibit

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