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ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC50 value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability.

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ALKBH5-IN-2 Chemical Structure

ALKBH5-IN-2 Chemical Structure

CAS No. : 1008951-10-7

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Based on 1 publication(s) in Google Scholar

ALKBH5-IN-2 Related Antibodies

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Description

ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC50 value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
1.38 μM
Compound: 121
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs
[PMID: 34792334]
HL-60 IC50
1.38 μM
Compound: 121
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs
[PMID: 34792334]
K562 IC50
1.38 μM
Compound: 121
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs
[PMID: 34792334]
In Vitro

ALKBH5-IN-2 (compound 6) (0-50µM; 48 h) inhibits cell viability with IC50s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALKBH5-IN-2 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Inhibited cell growth with IC50s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively.
Molecular Weight

209.20

Formula

C9H11N3O3
CAS No.
SMILES

O=C1NNC(C(C1)NCC2=CC=CO2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALKBH5-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALKBH5-IN-21008951-10-7OthersHEK-293TCCRF-CEMHL-60JurkatK562 cellscancercell viabilityInhibitorinhibitorinhibit

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