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  4. Alloc-Val-Ala-OH

Alloc-Val-Ala-OH  (Synonyms: ((Allyloxy)carbonyl)-L-valyl-L-alanine)

Cat. No.: HY-W076556
Handling Instructions Technical Support

Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

For research use only. We do not sell to patients.

Alloc-Val-Ala-OH Chemical Structure

Alloc-Val-Ala-OH Chemical Structure

CAS No. : 330970-70-2

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Alloc-Val-Ala-OH Related Antibodies

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Description

Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

Molecular Weight

272.30

Formula

C12H20N2O5
CAS No.
Appearance

Solid

SMILES

OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Alloc-Val-Ala-OH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alloc-Val-Ala-OH330970-70-2((Allyloxy)carbonyl)-L-valyl-L-alanineBiochemical Assay ReagentsInhibitorinhibitorinhibit

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