2. Others Metabolic Enzyme/Protease Apoptosis
  3. Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis
  4. Alogliptin-d3

Alogliptin-d3  (Synonyms: SYR-322-d3 free base)

Cat. No.: HY-A0023AS1 Purity: 99.61%
COA Handling Instructions

Molarity Calculator

Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].

For research use only. We do not sell to patients.

Alogliptin-d<sub>3</sub> Chemical Structure

Alogliptin-d3 Chemical Structure

CAS No. : 1133421-35-8

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1 mg USD 80 In-stock
5 mg USD 210 In-stock
10 mg USD 340 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Alogliptin-d3:

Alogliptin-d3 Related Antibodies

Top Publications Citing Use of Products

View All Dipeptidyl Peptidase Isoform Specific Products:

View All Isoforms
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].

IC50 & Target

DPP-4

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alogliptin-d3 Related Antibodies
Molecular Weight

342.41

Formula

C18H18D3N5O2
CAS No.
Unlabeled CAS

850649-61-5
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=O)C([2H])([2H])[2H])C=C(N2C[C@@H](CCC2)N)N1CC3=C(C=CC=C3)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (292.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (292.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (29.20 mM; ultrasonic and warming and heat to 60°C)

H2O : 10 mg/mL (29.20 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9205 mL 14.6024 mL 29.2048 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 2.9205 mL 14.6024 mL 29.2048 mL 73.0119 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL 14.6024 mL
10 mM 0.2920 mL 1.4602 mL 2.9205 mL 7.3012 mL
15 mM 0.1947 mL 0.9735 mL 1.9470 mL 4.8675 mL
20 mM 0.1460 mL 0.7301 mL 1.4602 mL 3.6506 mL
25 mM 0.1168 mL 0.5841 mL 1.1682 mL 2.9205 mL
DMSO / DMSO 30 mM 0.0973 mL 0.4867 mL 0.9735 mL 2.4337 mL
40 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8253 mL
50 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
60 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2169 mL
80 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9126 mL
100 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alogliptin-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alogliptin-d31133421-35-8SYR-322-d3Isotope-Labeled CompoundsDipeptidyl PeptidaseFerroptosisDPPInhibitorinhibitorinhibit

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