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  4. Alteplase

Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters.

For research use only. We do not sell to patients.

Alteplase Chemical Structure

Alteplase Chemical Structure

CAS No. : 105857-23-6

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Based on 1 publication(s) in Google Scholar

Alteplase Related Antibodies

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Description

Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters[1][2][3][4].

In Vitro

Alteplase ( 8.3 and 250 μg/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells)[4].
Alteplase (8.3 and 250 μg/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells[4].
Product Information
This product contains L-arginine, phosphoric acid, polysorbate 80, etc. as auxiliary materials. It is suitable for the treatment of acute myocardial infarction, acute massive pulmonary embolism with unstable blood flow, and acute ischemic stroke.

Instructions
The solution can be prepared with sterile water or normal saline (1 mg/mL).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alteplase Related Antibodies

Cell Viability Assay[4]

Cell Line: hfRPE cells
Concentration: 8.3 and 250 μg/mL
Incubation Time: 12 h
Result: Decreased the number of cells that adhered to the cell culture dish, i.e., the number of living cells following treatment of hfRPE cells with 83 μg/ml alteplase for 12 h and 250 μg/ml alteplase for 6 and 12 h.

Immunofluorescence[4]

Cell Line: hfRPE cells
Concentration: 8.3 and 250 μg/mL
Incubation Time: 0-6 h
Result: Increased The number of positive hfRPE cells for both EthD-III and FITC-Annexin V staining.
In Vivo

Alteplase (0.9-10 mg/kg, i.v., 20 to 40 minutes post ictus or 180 and 240 minutes post ictus) is beneficial when given early after stroke onset (<3 hours) and not beneficial when the administration is delayed (≥3 hours) in mice model of thromboembolic stroke[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice model of thromboembolic stroke[3]
Dosage: 0.9-10 mg/kg
Administration: i.v., 20 to 40 minutes post ictus or 180 and 240 minutes post ictus
Result: Significantly reduced the final infarct volume in the early stage.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Alteplase]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : ≥ 12.5 mg/mL

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

SDS (251 KB)

COA (230 KB)

Handling Instructions (2659 KB)
References
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Alteplase Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alteplase105857-23-6Actilyse ActivaseOthersPlasminogen ActivatorThrombolytic AgentInhibitorinhibitorinhibit

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