2. Neuronal Signaling
  3. Amyloid-β
  4. Valiltramiprosate

Valiltramiprosate  (Synonyms: ALZ-801)

Cat. No.: HY-117259 Purity: 98.83%
SDS COA Handling Instructions

Molarity Calculator

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.

For research use only. We do not sell to patients.

Valiltramiprosate Chemical Structure

Valiltramiprosate Chemical Structure

CAS No. : 1034190-08-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 121 In-stock
Solution
10 mM * 1 mL in Water USD 121 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 420 In-stock
50 mg USD 750 In-stock
100 mg USD 1370 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Valiltramiprosate Related Antibodies

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Description

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease[2].

IC50 & Target

β-amyloid[1]
In Vivo

ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

238.30

Formula

C8H18N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 30 mg/mL (125.89 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1964 mL 20.9820 mL 41.9639 mL
5 mM 0.8393 mL 4.1964 mL 8.3928 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (419.64 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.83%

SDS (252 KB)

COA (246 KB) HNMR (253 KB) LCMS (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.1964 mL 20.9820 mL 41.9639 mL 104.9098 mL
5 mM 0.8393 mL 4.1964 mL 8.3928 mL 20.9820 mL
10 mM 0.4196 mL 2.0982 mL 4.1964 mL 10.4910 mL
15 mM 0.2798 mL 1.3988 mL 2.7976 mL 6.9940 mL
20 mM 0.2098 mL 1.0491 mL 2.0982 mL 5.2455 mL
25 mM 0.1679 mL 0.8393 mL 1.6786 mL 4.1964 mL
30 mM 0.1399 mL 0.6994 mL 1.3988 mL 3.4970 mL
40 mM 0.1049 mL 0.5245 mL 1.0491 mL 2.6227 mL
50 mM 0.0839 mL 0.4196 mL 0.8393 mL 2.0982 mL
60 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7485 mL
80 mM 0.0525 mL 0.2623 mL 0.5245 mL 1.3114 mL
100 mM 0.0420 mL 0.2098 mL 0.4196 mL 1.0491 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Valiltramiprosate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valiltramiprosate1034190-08-3ALZ-801ALZ801ALZ 801Amyloid-ββ-amyloid peptideAβAbetaβ-amyloidTramiprosateAlzheimerdiseaseInhibitorinhibitorinhibit

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