2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin Kinesin
  4. AM-9022

AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer.

For research use only. We do not sell to patients.

AM-9022 Chemical Structure

AM-9022 Chemical Structure

CAS No. : 2446872-46-2

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Based on 1 publication(s) in Google Scholar

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Description

AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer[1].

In Vitro

AM-9022 (10-5-6 μM, 96 h) suppresses KIF18A-inhibitor sensitive cells growth with mean EC50value of 0.045 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM-9022 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: KIF18A-inhibitor sensitive (BT-549, HCC-1937, HCC-1806, MDA-MB-157, OVCAR-3), KIF18A-inhibitor insensitive (CAL-51, MCF-7, MDA-MB-453, ZR-75-1, OVCAR-5)
Concentration: 10-5-6 μM
Incubation Time: 96 h
Result: BT-549, HCC-1937, HCC-1806, MDA-MB-157, OVCAR-3 were sensitive to the compound with mean half-maximum effective concentration (EC50) value of 0.045 μM.
In Vivo

AM-9022 (30-100 mg/kg; p.o.; daily for 18 or 21 days) has significant anti-cancer effects in breast and ovarian tumor models at well-tolerated doses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice were injected with OVCAR-3 cells (5 x 106) subcutaneously in the right flank. Femal CB.17 SCID mice were injected with JIMT-1 cells (1.0 × 107) subcutaneously in the right flank) (6-8 weeks)[1]
Dosage: 30 mg/kg (OVCAR-3 CDX tumors mice); 30, 100 mg/kg (JIMT-1 tumors mice)
Administration: Oral gavage (p.o.); daily for 18 days or 21 days
Result: Increased pH3 mitotic marker levels in OVCAR-3 tumors by 3.4-fold, with higher compound exposure in tumors relative to plasma in OVCAR-3 CDX tumors mice.
Inhibited tumor growth, with evidence of tumor regression (TR) (95% TR, six of ten tumor-free mice) and no body weight loss in OVCAR-3 CDX tumors mice.
Inhibited tumor growth with evidence of TR (16% and 94% TR, respectively) at well-tolerated doses in JIMT-1 tumors mice.
The plasma AUC value at 30 mg/kg was 3.7-fold higher in the JIMT-1 model relative to the OVCAR-3 model.
Molecular Weight

578.67

Formula

C27H36F2N6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NS([C@H](C)CO)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC(C)=NC(N5CCC(F)(F)CC5)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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AM-9022 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-90222446872-46-2AM9022AM 9022Microtubule/TubulinKinesinKIF18A inhibitorcancermitoticchromosomal instabilityorally activeInhibitorinhibitorinhibit

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