2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AM12

AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.

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AM12 Chemical Structure

AM12 Chemical Structure

CAS No. : 2387510-84-9

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AM12 Related Antibodies

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Description

AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1].

IC50 & Target

IC50: 0.28 μM (TRPC5)[1]
In Vitro

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM12 Related Antibodies
Molecular Weight

349.13

Formula

C15H9BrO5
CAS No.
SMILES

O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM122387510-84-9AM 12AM-12TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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