2. Anti-infection
  3. Bacterial
  4. AM4085

AM4085 is an orally active Antagonist for FmlH with an IC50 of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma.

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AM4085 Chemical Structure

AM4085 Chemical Structure

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AM4085 Related Antibodies

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Description

AM4085 is an orally active Antagonist for FmlH with an IC50 of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma[1].

In Vivo

AM4085 reveals pharmacokinetic profils with good oral bioavailability in C3H/HeN mice[1]:

Pharmacokinetic Analysis of AM4085 in C3H/HeN mice[1]

route Dose (mg/kg) C0 (ng/mL) Cmax (ng/mL) T1/2 (h) Vdss (L/kg) CL (mL/min/kg) Tlast (h) AUC0-last (ng·h/mL) AUC0-inf (ng·h/mL) MRT0-last (h) MRT0-inf (h) AUCExtra (%) AUMCExtra (%) F (%)
iv 3 4427 - 1.47 1.42 13.6 8.0 3662 3736 1.59 1.75 1.90 10.8 -
po 10 - 1483 1.92 - - 8.0 6070 6564 3.18 3.75 7.55 21.6 52.7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

459.39

Formula

C21H21F4NO6
SMILES

FC1=CC=C(C2=C(C(F)(F)F)C=CC=C2O[C@@H]3O[C@H](CO)[C@H](O)[C@@H](O)[C@H]3NC(C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM4085 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM4085AM 4085AM-4085Bacterialurinary tract infectionsInhibitorinhibitorinhibit

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