AM580  (Synonyms: CD336; NSC608001; Ro 40-6055)

AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist^[1][2][3][4].

AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium^[1].
AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells^[2].
AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells^[3].
AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

351.44

C₂₂H₂₅NO₃

102121-60-8

Solid

White to off-white

CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

• [1]. Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23(1):31-45.e7.  [Content Brief]

  [2]. Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022  [Content Brief]

  [3]. Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31.  [Content Brief]

  [4]. Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110.  [Content Brief]