2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AM580

AM580  (Synonyms: CD336; NSC608001; Ro 40-6055)

Cat. No.: HY-10475G
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AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist.

For research use only. We do not sell to patients.

AM580 Chemical Structure

AM580 Chemical Structure

CAS No. : 102121-60-8

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10 mg USD 980 In-stock
50 mg USD 2800 In-stock
100 mg USD 4500 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of AM580:

AM580 Related Antibodies

Top Publications Citing Use of Products

    AM580 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284.  [Abstract]

    After dealing with 10 nM AM580 for 3 days, the expression of RARβ is detected by immunobloting and quantified.

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    RXRα RXRβ RXRγ

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    Description

    AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist[1][2][3][4].

    In Vitro

    AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium[1].
    AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells[2].
    AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells[3].
    AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    AM580 Related Antibodies
    Molecular Weight

    351.44

    Formula

    C22H25NO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    AM580 Related Classifications

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    The molarity calculator equation

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AM580 (GMP)102121-60-8CD336 (GMP) NSC608001 (GMP) Ro 40-6055 (GMP)RAR/RXRRetinoic acid receptorsRetinoid X receptorsGMPcell therapy manufactureMEFCiPSCSH-SY5Yneuronpromyelocytic leukemiamyeloid progenitorneutrophilInhibitorinhibitorinhibit

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